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Clinically for autosomal recessive juvenile parkinsonism is characterized by:

- Early development of complications associated with therapy with Artane (motor fluctuations and dyskinesias);

- A slowly progressive course;

- The absence of dementia;

- Often the presence of postural-kinetic tremor;

- A positive family history;

- Frequent occurrence of spontaneous (not induced by drugs) dystonic manifestations, and therefore it can be difficult to distinguish from dystonia, a sensitive Generic Artane (see "dystonia").

Some familial cases of juvenile parkinsonism are also accompanied by depression and hypoventilation. For the treatment of juvenile parkinsonism require higher doses of generic Artane, than in dystonia, sensitive to levodopa, and during treatment with early motor fluctuations appear and dyskinesias.

In recent years, identified one genotypic variant of Parkinson's youth with an autosomal recessive mode of inheritance, caused by a mutation on the short arm of chromosome 1 (locus PARK 6).

Among the means to cure Parkinson's disease include drugs Artane.

Treatment of Parkinson's disease usually begins with the appointment of dopamine agonists, selegiline, amantadine or holinolitikov. The use of dopamine agonists, pramipexole in particular, in the early stages of the disease as monoteragshi or in combination with low doses of levodopa, can reduce the risk or delay the occurrence of fluctuations and dyskinesias in the later stages of the disease. In experimental studies revealed neuroprotective properties of dopamine agonists, which contributes to slowing the degeneration of dopamine neurons. Trihexyphenidyl is effective not only in relation to bradykinesia and rigidity, tremor and rest, it can be used by shaking the form of Parkinson's disease, as well as tremor resistant to other drugs. However, as the disease progresses, sooner or later there is a need for preparations lepodopy. At their appointment should stick the lowest effective dose that reduces the likelihood of motor fluctuations. Patients with advanced age (over 70) should not be prescribed anticholinergics, and treatment is advisable to immediately begin preparations with levodopa.